Sentence examples for essential activation of the from inspiring English sources

The simulation of changes in isotopomer distribution induced by low doses of edelfosine revealed essential activation of the TCA cycle (including anaplerosis).

For the Ffh-FtsY heterodimer the essential activation function of the 3'OH is mediated in trans [ 20].

Previous structural and biochemical studies have suggested a mechanisms of Ire1 activation, whereby ADP binding to the phosphorylated protein promotes a conformational change that is essential for activation of the ribonuclease activity (Sidrauski and Walter, 1997; Lee et al, 2008).

CSR and SHM require the essential activity of the DNA activation-induced cytidine deaminase (AID).

Smad7 also disrupts the formation of the protein complex TRAF2/TAK1/TAB2/TAB3 (TNF-receptor associated factor 2/TGFβ-activated kinase 1/TAK-binding protein 2/3), which is essential for activation of the inflammation cascade (Hong et al., 2007).

Further reorientation of the cullin and RBX1 RING domain is essential for activation of the RING E3 ligase complex to bridge the ∼50 Å gap between the ubiquitylation substrate and the ubiquitin-bound E2 E2zymE2,11.

Kisspeptin and its G protein-coupled receptor (GPR) 54 are essential for activation of the hypothalamo-pituitary-gonadal axis.

The first is typical for sGCs, where binding of NO to the H-NOX domain is essential for activation of the GC.

Accumulation of p53 in response to DNA damage is essential for activation of the response pathways.

Ligand binding induces receptor hemo- or heterodimerization that is essential for activation of the tyrosine kinase.

In this study, we show that TAF4 is essential for activation of the post-natal hepatocyte gene expression programme.