In essence, the underlying pathophysiology of HFpEF is poorly understood largely owing to the presence of multiple co-morbidities such as hypertension, diabetes, metabolic syndrome, atrial fibrillation, and renal and vascular disease, which impact the pathogenesis of this syndrome and contribute to the complexity of mechanisms governing cardiac remodeling [ 86].
Scheler combined the interests of an empirical scientist with a philosophical effort that followed in the tradition of 19th-century attempts to relate human experiences to the concept of a reality (essence) that underlies human thoughts and activities.
A fundamental and challenging issue is how an information landscape can be designed such that it will not only preserve the essence of the underlying information structure, but also accommodate the diversity of individual users.
In an attempt to best capture the essence of the underlying concepts and practices, the term gamification has been defined in several ways, such as "the use of game design elements in non-game contexts" (Deterding, Dixon, Khaled, & Nacke, 2011), "the phenomenon of creating gameful experiences" (Hamari, Koivisto, & Sarsa, 2014), or "the process of making activities more game-like" (Werbach, 2014).
For example, many think that new functional traits appear in organisms when they are needed; that evolution consists of the transformation of an entire species' underlying essence; that it necessarily implies "randomness," "progress," or increasing complexity; or that it is mathematically improbable or violates the second law of thermodynamics.
This paper illustrated just some of the possible consequences that stem from the comforting but ultimately erroneous assumption that accounting for quality is a matter of capturing the preexisting and underlying essence of quality through the application of timeless and technical scientific principles.
The erasure of sexual difference enables a metaphysics of substance in which sexual identity is a matter of fixed and pre-determined being, of underlying essences or common properties, rather than a form of becoming and self-generation.
For human beings, the intellect assumes the mantle of substance (Mahdi, 125), it being "a principle underlying the essence of man," both an agent and final cause (Mahdi, 122).
And through analyzing the distributions of attack of angle and drag in rotor disk, the underlying physical essence of ECR power reduction is cleared.
