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High vaccination coverage of heifers is recommended, especially when targeted to areas where large-scale extensive cattle production predominates.
In addition the present findings identify A2MG containing microparticles or microvesicles as a potential therapeutic intervention in patients suffering from severe sepsis/septic shock, especially when targeted to patients with immune compromise and recurrent or persistent sepsis.
Analysis of AnPGI fused with elastin-like polypeptide (ELP) revealed a significant increase in the protein accumulation level, especially when targeted to the vacuole where the protein doubles its accumulation to 3.6% of TSP, while the hydrophobin (HFBI) fusion impaired AnPGI accumulation and both tags impaired activity, albeit to different extents.
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Furthermore, FLT has been suggested as surrogate marker for assessment of response to treatment, especially when targeted drugs are utilized.
This knowledge could be used to inform clinical decisions, especially when targeted therapies are considered.
Multiplexing and automation will become more important in the future, especially when targeted sequencing is being used instead of genotyping in studies involving a large number of samples.
This type of negative control is necessary especially when targeting overlapping RNA to insure that the signal generated is specific to the targeted RNA strand and not to the reverse overlapping RNA.
However, there are several limitations to this immunotherapeutic strategy, especially when targeting a single antigen.
Control for the latter should be mandatory in case control studies in order to avoid false positives, especially when targeting 'African-Americans' for which one might a priori suspect large differential matrilineal admixture proportions in cases and controls [ 33].
Moreover, it may have a positive impact upon coping resources, especially when targeting disadvantaged groups with low health literacy who have the most to gain from efforts to improve their self-management skills [ 6, 44].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com