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This strategy aimed at selecting the most robust gene expression changes present through multiple time-points and helped us to efficiently eliminate the "zigzagging" expression profiles especially observed with genes expressed at low level (raw expression <100, see methods).
We find that CSMN are prone to cellular degeneration in the absence of UCHL1 function, and undergo early and progressive cytoarchitectural defects, especially observed with disintegration of apical dendrites.
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However, in general ZF leads to noise amplification, which is especially observed in systems with the same number of transmit and receive antennas.
Despite its teratogenic effects, thalidomide has been reintroduced in human anticancer treatment for its anti-angiogenic activity, especially observed in patients with multiple myeloma.
This reduction was more dramatic at high effector:target ratios and especially observed when combined with anti-αGal antibodies (5-fold difference).
This was especially observed during July 2006 with a significant drought induced by a decrease in precipitation ranging from 18 to 8 mm from June 18 to July 3 2006, followed by 12 continuous days without rains (Fig. 1e).
These alterations were especially observed in patients with advanced atherosclerosis, when developing acute-coronary syndrome or diabetes mellitus [ 6, 7].
This was especially observed during July 2006 with a significant drought induced by a decrease in precipitation ranging from 18 to 8 mm from June 18 to July 3 2006, followed by 12 continuous days without rains (Fig. 1e).
A decrease in coverage was especially observed in regions with low GC content (<25%) when the heat-inactivation protocol was applied (examples are displayed in Additional file 2: Figure S1).
In summary, loss of DNAm during culture expansion is especially observed in heterochromatin associated with the nuclear lamina, whereas DNA hypermethylation was observed in regions not associated with the lamina.
The prognostic effect of post-chemotherapy CD68 infiltration was especially observed in those patients with residual tumor (no pCR), in whom a higher CD68 count trended to associate with worse DFS in univariate (P = 0.055) and multivariate analysis (P = 0.09; HR = 2.26, 95% CI: 0.86 to 5.96).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com