Sentence examples for especially in exon from inspiring English sources
Commercially available probe-based allele-specific PCR exhibited relatively poor performance when detecting very low copies of mutated DNA, especially in exon 19 and 20.
In the current study, PIK3CA mutations were identified in 11 tumours (9.8%) and, more especially, in exon 9 than in exon 20; this observation is in contrast with that observed in the Sartore-Bianchi's et al [21] cohort but in agreement with that reported by Prenen et al [26].
PIK3CA mutations, especially in exon 9, were significantly associated with grade I-II tumors.
A target sequence with the least number of off-target sites, especially in exons, should be selected.
As Tet1 binds to both CGI promoters and exons [ 46, 51, 52], this suggests that a certain 'event' stabilizes 5-mC in gene bodies, especially in exons.
The results in this report support our previous proposal, suggesting that DNA methylation is more directly involved in dictating nucleosome organization, especially in exons and CpG islands.
Furthermore, it is well known that the Alu elements are highly polymorphic [ 29] or highly aperiodic and that a marked reduction of Alus is located within the interrupted genes, especially in exons [ 6].
Several groups have reported 5-hmC mapping by deep sequencing in mESCs and showed that gene-rich regions are particularly abundant in hydroxymethylcytosine, mostly at unmethylated CGI promoters and in the gene bodies of (highly) transcribed genes, especially in exons where methylation is also found.
Note that an LRTS was found more frequently in the last CDS exon, especially in the exon untranslated region, and less frequently in internal coding exons (Table 3).
The number and lengths of the exons and the locations of the exon/intron boundaries were very similar to cortactin, especially in the exons that encode the actin-binding domain (compare [see Additional file 1] and [see Additional file 2]).
Our results, especially in the exons and CpG islands, revealed many important features in the chimpanzee genome, or more broadly, in mammalian genomes.
