Although it is unlikely that the resulting selectivity of this approach will be complete, since, at the time of treatment with the second drug, some normal cells will be in S phase and will be killed while other tumor cells will be in other phases of the cell cycle and will escape, the relative timing of the two drugs could be optimized to maximize therapeutic gain.
The second goal was classic "Chicharito", escaping his marker, timing his run to the near post perfectly and getting on the end of a cross from the left with a clinical finish.
The second goal was classic 'Chicharito', escaping his marker, timing his run to the near post perfectly and getting on the end of a cross from the left with a clinical finish.
A true Grand Slam — winning all four tournaments in the same calendar year — would close those gaps in a hurry, but it remains a long shot for Williams, who has not won the French Open since 2002 and who has been prone to unexpected episodes of extreme tightness when she pirouettes, fingers splayed after errors, and her timing escapes her.
Notice, that the courses of the escape at the deterministic timing (i.e. at time delays) of the TPN transitions and those at the non-deterministic timing (namely at the exponential probability distribution) are indeed different but comparable as to shapes of the curves.
The party's current leader, Ed Miliband, doesn't escape unscathed and the timing could hardly be worse for him.
We compared the estimate of the timing of escape starting across the vaccination groups (Fig 2E).
While the precise timing of escape has been debated, it has been reported that during the first hour after host cell entry there is evasion of phago-lysosomal fusion and escape into the host cell cytosol [7], [8].
Little is known about the early hierarchy in targeting CTL epitopes and relative immunodominance, the timing of escape mutations, and how efficient novel CTL responses can be generated towards epitope variants in acutely infected humans.
We explore all possible orderings of the latter four events to evaluate the effect of the timing of escape relative to other life-history events.
