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Besides, while part of free Dtx molecules, transported into the cytoplasm by a passive diffusion, were transported out by P-glycoprotein (P-gp) pumps, NPs are taken up by cells through an endocytosis pathway, thus resulting in a higher cellular uptake of the entrapped drug [22], thereby enabling them to escape from the effect of P-gp pumps.
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Like all moving mechanical devices, automobiles cannot escape from the effects of friction.
The Power of Nutrition will save lives and help millions of children escape from the effects of malnutrition.
In the ecotype model, a new ecotype forms when the acquisition of an adaptive mutation allows a derived population to invade a new ecological niche and escape from the effects of drift and selection imposed by the ancestral population.
Although the dosage of KI was gradually reduced to 50 mg 3 days per week, the escape phenomenon from the effect of excess iodide was not observed and serum TSH level remained detectable (3.62 mU/L) until April 2008.
One study [ 15] suggests that impaired urinary excretion of iodide is also responsible for elevation of serum iodide levels and that urinary iodine excretion might play an important role in the escape phenomenon from the effect of excess iodide.
Today's fugitives, like their predecessors, are also escaping from the effects of a currency union.
Lack of response to antiviral treatment is presumably associated with the ability of viral populations to escape from the deleterious effects of the effective agent(s).
KI therapy in now not popular because it is believed that escape from the KI effect is observed.
Despite many complicated mechanisms of MDR such as blocking cell apoptosis, alteration of the drug target protein, activation of DNA repair, decreased drug uptake and increased drug efflux [ 3], cancer cells can escape from the toxic effect of drugs mainly due to the highly expressed membrane transporters that pump drugs out of cells [ 2].
This stem cell-like property is necessary for normal breast tissue functioning, but it is also fuel for cancer cells to survive and duplicate, helping them to escape from the suppressive effects of immune cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com