ESCAPE FROM CAMP 14, by Blaine Harden.
"If the U.S. just wants to escape from Afghanistan without a responsible exit strategy, that will send a clear message to the Taliban, al-Qaida and the Haqqani network that it's safe".
In addition to these well-studied mechanisms of resistance, there are additional mechanisms that are in the early phase of investigation, such as the up-regulation of novel resistance genes responsible for escape from dependence on ΔEGFR in GBM [70].
Most intriguingly, are tumor-changing phenotypes responsible for cancer cell escape from recognition by an adequately activated immune response?
It has been suggested that Dll4/Notch signaling might be involved in resistance to anti-VEGF therapy [ 67], and that this pathway might be responsible for the escape from anti-angiogenic therapy.
The limited numbers of CSCs in the tumour cell population and their specific phenotypes are considered responsible for their escape from conventional cancer therapies resulting in disease relapse (Pardal et al, 2003).
Because cancer stem cells are believed responsible for tumor metastasis, escape from anticancer therapies and ultimately disease relapse, their therapeutic targeting is crucial [58], [59].
Hence, the limited number of CSCs in the tumour and their specific phenotype are held responsible for tumour cell escape from conventional cancer therapies, resulting in disease relapse (Wegner, 1999; Graham et al, 2003).
Importantly, LOX catalytic activity was found to be responsible for LOX-triggered escape from senescence: this escape was completely blocked upon addition of 3-aminopropionitrile (BAPN), an inhibitor of the catalytic activity of all the LOX proteins, and a catalytically inactive LOX form proved unable to induce senescence reversal (Supplementary Figure 2).
Arlott's memory was lauded only last month on the death at 80 of Basil D'Oliveira, for John was responsible for Dolly's initial "escape" from South Africa's wretched racial bondage in the 1960s.
