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Elimination of damaged mitochondria by autophagy serves as a rescue mechanism for cells to escape from cell death (Codogno and Meijer, 2005).
Cells in Src clone could escape from cell death if JNK pathway is blocked [ 35].
Here, we addressed this issue and identified a novel regulatory loop which allows EGC cells to escape from cell death.
In this study, HB-EGF was attributable for the escape from cell death, as SN38 damaged OCCC cells.
If CSCs naturally resist environmental stresses, it would be speculated that this population may also escape from cell loss during tumor progression.
Overexpression of Bcl-2 in tumor cells can produce tolerance to a variety of anticancer drugs and mediate escape from cell death.
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Conversely, the lack of RASSF9 expression in RASSF9−/− mice means that p21Cip1 expression is not sufficiently up-regulated in keratinocytes progressing to early differentiation, allowing these keratinocytes to escape from cell-cycle withdrawal and potentially accounting for the epidermal hyperplasia observed in these mice (Figure 14B).
The rapid and highly cytopathic replication cycle of rhinoviruses (and enteroviruses) that seems designed to infect and escape from cells before IFN-mediated responses become effective, may indeed have a more general interfering effect on more sensitive RNA (and DNA viruses) that infect the respiratory tract.
Therefore, we analysed whether KRAS-facilitated apoptosis induction by 5-FU and oxaliplatin was accompanied by escape from cell-cycle arrest.
Upon Rb deletion, cells escaped from cell cycle arrest and began replicating at levels equivalent to the original untreated cell population (Figure 2C, left panel).
The current data demonstrate that tumor cells escaping from cell loss and surviving in the late-stage tumors contain CSC-like characteristics.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com