Sentence examples for escape dormancy from inspiring English sources

This implies that neoplastic cells could escape dormancy even if angiogenesis is still suppressed.

Therefore, we sought to find correlates of stromal activation in the expression analysis of malignant breast epithelial cells, and determined if tumor-induced changes in the stroma can serve as a surrogate for stromal activation, including the likelihood to escape dormancy.

The kinetics of overt metastasis development (here observed to occur at median 15 months, range 1 59 months after primary surgery) further suggests that DTC may be representative of dormant tumour cells with the ability to escape dormancy control to self-renew and differentiate upon receiving an appropriate stimulus (McGowan et al, 2009).

So it would appear that starting an antiangiogenic therapy before surgery and continuing it to prevent micrometastases from escaping dormancy would interfere with wound healing after primary tumor removal.

This has been explained by escape from dormancy using, for example, immunosurveillance [2 6].

Thus, escape from dormancy and late relapse could be associated with increased proliferation in CTCs.

The molecular mechanisms underlying latency and relapse remain unknown and although the patients' compromised immune system is undoubtedly a contributing factor, changes in the fungal genome may aid the escape from dormancy at the opportune moment.

When treated with a Dll4 therapeutic antibody, endothelial cells become hyperproliferative leading to a capillary and defective vascular phenotype 3. Notch regulates the interactions between endothelial and tumor cells, which enables tumor cells to escape from dormancy 4.

In our study, metastatic patients who recurred after 5.5 to 10 years following surgery, were included as a control group for the evaluation of CTCs in a condition that resembles escape from dormancy.

In accordance, studies using preclinical models suggest that escape from dormancy is associated with cellular proliferation driven by microenvironmental signals leading to extracellular signal-related kinase (ERK) activation [ 50, 51].

We describe a role for hormones in development of luminal metastases, the cellular heterogeneity of micro- and macrometastases arising from apparently homogeneous cell models, a PR− dormant state that may be a sanctuary from therapies, and a role for hormones in escape from dormancy.