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Unmethylated CpG sites escape depletion and are clustered in relatively small areas called CpG islands.
In contrast, switched memory B cells escape depletion despite their surface expression of CD20.
Several studies have shown that mature B cells can escape depletion even though they express CD20 [ 49- 51].
The properties of B cells leading to rituximab resistance and helping 30% of human BM B cells to escape depletion are elucidated.
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Translations were also performed in the absence or presence of dominant-negative eIF4A (eIF4A R362Q [35]) to inhibit the activity of any residual eIF4G that had escaped depletion.
In these cases, it might be possible that residual amounts of condensin II, which have escaped depletion, are sufficient for the first two steps of chromosome condensation.
Since the parasites live and replicate within the macrophages of the human host, it seemed conceivable that they might escape polyamine depletion by obtaining polyamines from the host cell [ 90].
To further evaluate the phenotype of B cells escaping rituximab depletion in BM, a combination of CD27 and IgD was used.
Typically, 2-4 x 10 cells are recovered per tissue, but recovery may be higher if many immature erythrocytes have escaped the depletion procedure.
Collectively, escape from CD20 depletion combined with increased BAFF levels could provide additional survival signals to residual pathogenic B cells during rituximab therapy.
The extensive use of the area by trawler fleets from many nations in the mid-20th century created several international incidents, led to overfishing, and necessitated regulating the size of net mesh used so that the small fish could escape, thus safeguarding against depletion.
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