Sentence examples for escape deletion from inspiring English sources

Here, we describe the thymic development of MART1-specific autoreactive CD8+ T cells that normally escape deletion and how their phenotype and survival are affected by introduction of the missing epitope in the hematopoietic lineage.

Thus, in spite of the thymic cortex being largely devoid of DP thymocytes in male mice, some cells develop normally if they escape deletion by the early expression of endogenous TCRα chains.

These cells are thought to be essential for maintaining tolerance to self-antigens recognised by autoreactive T cells that escape deletion in the thymus (Sakaguchi, 2005).

However, B cells expressing immunoglobulin receptors with low affinity for self-components can escape deletion and receptor editing, and enter the peripheral circulation and lymphoid organs.

5 It is hypothesised that reduced T-cell signalling may occur as a result and, in turn, this may enable auto-reactive T cells to escape deletion during thymic selection and thus persist in the circulation to become activated at a later stage.

The sustained expression of PD-1 is associated with T-cell exhaustion in the setting of chronic viral infection (Wherry et al., 2007; Virgin et al., 2009; Wherry, 2011), and exhaustion associated with PD-1 might support the maintenance of tolerance in low-affinity autoreactive T cells that escape deletion in the thymus and are chronically exposed to components of self in the periphery.

All through the day and night it ploughs on, screening 60s television detective series such as Public Eye, starring Alfred Burke, which miraculously escaped deletion at a time when whole Wednesday Plays and episodes of Dad's Army were erased by the BBC to cut storage costs.

Interestingly, those T cells that escaped deletion after apoptotic cell infusion exhibited reduced percentages of IFN-γ-secreting cells and increased numbers of IL-10-releasing cells and FoxP3+, compared with controls treated with donor splenocytes alive.

We examined frequency of Vβ11+ lymphocytes escaping deletion in F1 mice.

We reasoned that p(I C -induced deletI C -inducedmplete in vivo andeletionome cells escaped deletion.

Mcl-1f/fLckCreBak+/− thymocytes contain wild type levels of Mcl-1, likely because surviving thymocytes have escaped deletion of Mcl-1.