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Simulated genes that escape Blast detection, and are thus not classified as Old, will tend to be fast evolving genes, creating an obvious correlation, as can be seen in Figure 2B, and even more exaggeratedly in Figure 2C.
However, this cannot explain the observed relationship between gene age and evolutionary rate [ 16], since the fact that genes that escape Blast detection evolve fast does not mean that all fast genes escaped Blast detection.
As all genes were evolved along the same tree, as if they were Old, the number of real genes expected to escape Blast detection is directly reflected in the distributions of simulated genes falling in the "Metazoans", "Deuterostomes", and "Tetrapods" categories.
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