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Huzmulu et al. [ 29] also corroborated the high rate of grade 3-4 toxicities with radiation dose escalation using the conventional radiotherapy technique.
Toxicity was assessed at 1, 2, and 3 months after the starting date of the tamoxifen dose escalation using the National Cancer Institute Common Toxicity Criteria for Adverse Events, version 3.0.
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Dose escalation used the standard "3 + 3" design up to full dose of both agents.
This study was undertaken to determine the feasibility of dose escalation using proton therapy, as compared to conventional 3-dimensional conformal radiation, by minimizing the dose to normal tissues.
The resultant analytic model is applied to the case of the Channel Fixed Link using a hindsight approach to explore the dynamics of escalation using history for generating theory in project management research.
In recent years, the introduction of stereotactic ablative radiotherapy (SABR) has offered even more intensive tumor dose escalation using a hypofractionated regimen with reduced dose to the normal liver, usually below the threshold dose above which severe RILD is observed.
These findings have stimulated interest in assessing the feasibility of dose escalation using a modified CHART schedule.
In our study we wanted to evaluate the role of dose escalation using conformal radiotherapy in conjunction with initial androgen suppression.
In view of the relatively high starting doses, it is not surprising that the combination MTD was established after a single dose escalation using a conventional 3+3 phase I study design.
These include dose escalation using interstitial brachytherapy (IB) with conformal EBRT, accelerated or altered fractionation, and radiosensitization with the addition of chemotherapy.
The aim of this study was to assess specific, target-mediated uptake in normal tissues, with immuno-PET in a phase I dose escalation study, using the anti-CD44 antibody RG7356 as example.
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