Suggestions(2)
Exact(3)
These findings have stimulated interest in assessing the feasibility of dose escalation using a modified CHART schedule.
In recent years, the introduction of stereotactic ablative radiotherapy (SABR) has offered even more intensive tumor dose escalation using a hypofractionated regimen with reduced dose to the normal liver, usually below the threshold dose above which severe RILD is observed.
In view of the relatively high starting doses, it is not surprising that the combination MTD was established after a single dose escalation using a conventional 3+3 phase I study design.
Similar(57)
This study was structured as a dose-escalation using a modified Fibonacci design to govern dose escalation towards a MTD (Fig 1).
The resultant analytic model is applied to the case of the Channel Fixed Link using a hindsight approach to explore the dynamics of escalation using history for generating theory in project management research.
We searched for a definition of rapid dose escalation using keywords "antipsychotic", "neuroleptic", "rapid dose escalation", "rapid titration", and "rapid increase".
Based on the results of this planning study, we will start a clinical phase I/II study of focal dose escalation using PET-guided IMRT for patients with postoperative local recurrent rectal cancer in our institution.
The design was a single blind, across subjects, placebo controlled, group wise dose escalation using doses of 20, 35, 50 and 100 mg β-methyl-6-chloromelatonin.
Our goal was to evaluate a voxel-based biomarker, the functional diffusion map (fDM), as an imaging biomarker to detect heterogeneity of tumor response in a radiation dose escalation protocol using a genetically engineered murine GBM model.
In their latest report, Takahashi et al. showed the preliminary results of a phase I/II trial as a dose escalation study using a single fraction [ 25].
We evaluated a combination of 5-FU, mitomycin C and radiotherapy in a phase I dose escalation study using a similar schedule adapted from that used in UKCCCR anal carcinoma study (UKCCCR working party, 1996).
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