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In Fig. 6 a, we observe that all the studied protocols gain rapid throughput escalation up to approximately 46 SUs per CRN, since the system resources can tolerate additional traffic from SUs.
Dose escalation (up to 320 IU m−) was allowed in patients who had stable disease.
IFX intensification was defined as a dose escalation (up to 10 mg/kg) and/or shorter intervals between infusions (every 4 6 weeks).
Intensification of IFX treatment was defined as a dose escalation (up to 10 mg/kg) and/or a shorter interval between infusions (every 4 6 weeks).
Twenty-one patients with cutaneous melanoma received a starting dose of 160 IU m− (four of whom had dose escalation up to 320 IU m−).
Owing to grade 2 renal toxicity in cycle 1 of a patient at 40 mg m−2, reported as a serious adverse event (SAE), the study entered stage 2 with a dose escalation up to 120 mg m−2 according to modified Fibonacci method.
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The dose-escalation up to 800 mg/d was allowed in case of disease progression.
As it turned out, dose-escalation up to 800 mg/d presented no clinical benefit when compared with a dose of 400 mg/d [ 77].
Patients originally assigned to infliximab could receive dose escalations up to 7.5 mg/kg starting at week 36 if their Bath Ankylosing Spondylitis Disease Activity Index score was at least 3 for two consecutive visits.
The fact that your escalation goes up to $310,750 does not mean you'll wind up paying that price for the home.
In view of the low toxicity seen in the intravenous arm, allowing dose escalation of up to 75 mCi, it may be feasible to combine KAb201 with I131 given by the intravenous route with chemotherapy, as has been demonstrated in a preclinical study [ 44], or erlotinib, to improve efficacy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com