Sentence examples for escalation trials from inspiring English sources

Pneumonitis and fibrosis after 3-dimensional conformal high-dose radiation are reviewed, including recent updates from radiation dose escalation trials.

The purpose of this review is to evaluate the methodology used in published phase I radiotherapy (RT) dose escalation trials.

Preclinical studies of the type described in this report must be combined with surrogate imaging agents to establish safe starting activity levels for phase I dose escalation trials.

However, few dose escalation trials planned to incorporate M&S into decision making.

Dose limiting toxicities were observed in dose escalation trials but a maximum tolerated dose was not established.

Dose escalation trials in pretreated populations of MM patients proved promising, but with higher rates of severe AEs reported in the carfilzomib study.

Design: Randomized, controlled, single-blind phase II dose escalation trial.

Design: Controlled, single-blind, parallel-group phase II dose escalation trial.

This was a dose escalation trial designed to determine the safety and tolerability of intracoronary rhVEGF infusions.

We present a Phase I dose escalation trial design based on a modified continual reassessment method that allows for sharing of information between populations.

Based on these studies, we proposed a phase 1 dose escalation trial followed by a phase 2 randomized, double-blind, placebo-controlled clinical trial of human MSCs for the treatment of moderate-severe ARDS.