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Design: Randomized, controlled, single-blind phase II dose escalation trial.
Design: Controlled, single-blind, parallel-group phase II dose escalation trial.
This was a dose escalation trial designed to determine the safety and tolerability of intracoronary rhVEGF infusions.
De Wolf, K. et al. Combined high dose radiation and pazopanib in metastatic renal cell carcinoma: a phase I dose escalation trial.
We present a Phase I dose escalation trial design based on a modified continual reassessment method that allows for sharing of information between populations.
Although 8 patients (27%) experienced adverse radiation effects (ARE) on this dose escalation trial, it was not associated with a statistically significant decline in any of the primary HRQOL scales.
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Observations from a randomized dose-escalation trial for malignant glioma (Radiation Therapy Oncology Group 83-02).
Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma.
Martinsson, L. & Wahlgren, N. G. Safety of dexamphetamine in acute ischemic stroke: a randomized, double-blind, controlled dose-escalation trial.
Raez, L. E. et al. A phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors.
Lee, D. W. et al. T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial.
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