Sentence examples for escalation stops from inspiring English sources

If two or more DLTs occur, escalation stops and the dose is de-escalated to the next lower level (Chin and Lee, 2008).

If two or more patients out of the six exhibited DLT, the maximum tolerated dose (MTD) was supposed to be surpassed and dose escalation stops at that level.

If two or more patients out of the six exhibit a DLT, the dose escalation stops at that level and the next lower level is considered as the MTD.

If two or more patients out of the six patients treated at this dose exhibit a dose limiting toxicity, the dose escalation stops at that level and the next lower dose is considered as the MTD.

"It's going to be a challenging market," said a third, and the escalation stopped there.

Dose escalation stopped if DLTs were observed in two or more patients during one cohort.

Dose escalation followed a 3+3 design; cohort expansion to six patients was required if one DLT was reported, and dose escalation stopped if two DLTs were observed.

If two or more patients had DLTs at any dose level, dose escalation stopped, and this dose level was considered the MTD.

Escalation stopped as soon as two or more patients experienced a DLT attributable to the study drugs in the first cycle at the given dose level.

The study was ended by the Sponsor following completion of the 0.25 mg/kg dose level based upon protocol-defined dose escalation stopping rules related to increases in hemoglobin levels.

As such, we might consider also the four D's of nutritional therapy in analogy to how we deal with antibiotics and fluids [5]: drug (type of feeding), dose (caloric and protein load), duration (when and how long) and de-escalation (stop enteral nutrition and/or parenteral nutrition when oral intake improves) [37].