The escalation in genome sequencing has presented a mass of potentially useful new alcohol dehydrogenases (ADHs) in the form of putative open reading frame (ORF).
The dose-finding step was designed as an open-label, single sequence dose escalation, single-dosing study to determine the lowest oseltamivir dose detectable in plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and showing dose-linearity with two higher oseltamivir doses.
This study has several limitations that are inherent to fixed-sequence dose escalation studies.
Proper throughput escalation, sample multiplexing and adequate sequence coverage may potentially turn ultrasensitive genotyping into a feasible strategy for HIV drug resistance management in the clinical setting.
The sequence of dose escalation progressed from 100 to 150 mg once daily (QD), and then to 225 mg QD, which was the maximum administered dose.
The past three years have seen an escalation in the number of sequenced bacteriophage genomes with more than 500 now in the NCBI phage database, representing a more than threefold increase since 2005.
In fiction works, the sequence of events or escalation of suspense is often described as; Chase the man to a house Shoots bullets at the house.
With the escalation of high throughput prokaryotic genome sequencing, there is an ever-increasing need for databases that characterise, catalogue and present data relating to particular gene sets and genomes/metagenomes.
(One way to read this last sequence is as a logical escalation: he targeted Hispanics, saw his poll numbers soar, and then targeted another group that was less popular — Muslims).
