Exact(34)
In the first cohort only, a dose escalation scheme was applied where study drug was not escalated to the next dose level unless the safety and tolerability of the previous doses were acceptable by sponsor and clinical team.
Interestingly, when calcitriol treatment was discontinued after the escalation scheme this sensitization benefit was lost.
Additionally, we also investigated the "long-term" calcitriol cryosensitization potential using an in vitro dose escalation scheme.
Additionally, maintenance of 80 nM calcitriol for 20 days after the escalation scheme resulted in complete cell death at the −25 °C isotherm with no re-growth after 3 days.
The dose escalation followed a conventional dose escalation scheme.
The dose escalation scheme is summarised in Table 1.
Similar(26)
As it was anticipated that myelotoxicity might be dose limiting even at dose level 1a, further (lower) dose escalation schemes were devised.
CRS related adverse events may be reduced by designing safer CARs and CAR-T cells and following strict dose-escalation scheme.
An interpatient dose-escalation scheme was used.
The actual dose-escalation scheme achieved is shown in the results section (Table 1).
The actual study dose-escalation scheme is shown in Table 2 >.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com