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A two center, dose escalation phase I study of rViscumin was carried out.
A succeeding market escalation phase, lasting until 2016, then foresees the introduction of EVs into the market and a broader infrastructure installation that covers numerous towns.
In this paper, we focus on the dose escalation phase prior to the DEC, with the purpose of adapting it to the needs of DEC.
It is made up of two phases: a dose escalation phase with 15 patients and an extended pivotal phase with an additional 55 patients.
Patients (n=63) were transitioned from valproate to lamotrigine during an 8-week escalation phase followed by 24 weeks of lamotrigine monotherapy.
This was an open-label, dose escalation phase I trial.
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Testing preload dependence may also be helpful in the de-escalation phase of shock management.
It is thus imperative that fluid management strategies include a de-escalation phase to optimize fluid balance [87].
After initial haemodynamic stabilisation, during the de-escalation phase, EVLWI may be helpful in instituting an aggressive but controlled fluid removal strategy.
Similar to the dose-escalation phase of the study, all data was electronically reported within the format of this COTC multi-center trial design.
Dogs with metastatic disease were excluded from entry in the dose-escalation phase (Table 1) but were allowed in the multiple-dosing phase of the trial (Table 2).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com