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Identification of an appropriate biomarker would aid clinical decision-making regarding escalation of therapy as well as selection for clinical trials with novel therapies.
Patients hospitalized with acute heart failure may experience worsening symptoms requiring escalation of therapy.
A subset of patients hospitalized with acute heart failure experiences worsening clinical status and requires escalation of therapy.
Approximately 60% of patients, including 8 of 10 receiving anakinra monotherapy, attained a complete response without escalation of therapy.
In-hospital worsening heart failure represents a clinical scenario wherein a patient hospitalized for acute heart failure experiences a worsening of their condition, requiring escalation of therapy.
Moreover, this predictability was not influenced by the clinical grade of the SAH, an observation that can lead to an unbiased and more attentive attitude toward patients at theoretical risk of DIND and establish lower threshold for their investigation and escalation of therapy when necessary.
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De-escalation of therapy is inherently a non-inferiority question.
An appropriate response to this information often involves de-escalation of therapy or even its discontinuation.
In 350 (44.9%) patients, neither escalation nor de-escalation of therapy was done.
To prevent resistance, current practice dictates prompt de-escalation of therapy in response to culture results.
De-escalation of therapy may be guided by scores such as the clinical pulmonary infection score (CPIS) [ 53].
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