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If antimicrobial change consisted of escalation and de-escalation (i.e. switch to or addition of an antibiotic with a broader spectrum but also withdrawal of another antibiotic), the patient was assigned to "escalation group" for statistical analysis.
Moreover, significantly more ACR50 responses were observed in the fast escalation group.
Small to moderate effect sizes for clinical variables were found in the methotrexate escalation group (range 0.09 0.67) and the placebo escalation group (range −0.22 0.82), without any significant differences between the groups (fig 1C).
Besides, the proportion of HLA-DR+CD3+ T-cells decreased in the "swift" group but not in the "slow" escalation group [ 75].
The pooled effect size ranged from −0.38 in favour of the placebo group to 0.33 in favour of the escalation group.
Although in the fast escalation group significantly more patients experienced adverse events, the nature of the events was similar (table 2).
Similar(53)
During phase I, the escalation groups consisted of 7 (5 mg/m2 PEG-Dox), 4 (10 mg/m), 3 (15 mg/m) and 4 (20 mg/m) patients.
People are divided into committees, including town planning, child care, direct action and a de-escalation group charged with keeping things orderly.
We found no differences in hospital long of stay between de-escalation group comparedto those who did not received it.
Finally, the number of days alive without SAT at day 28 was higher in the de-escalation group (14 days [5; 23]) than in the no de-escalation group (10 days [2; 17] p < 0.01) leading to a median cost difference of 1100 euros in favor of de-escalation group.
We also found a significant lower hospital mortality in de-escalation group in front of the others (25.9 vs. 43.1 %; p < 0.001).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com