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Mechanism-based side effects may limit dose escalation further, resulting in suboptimal target engagement and impaired efficacy.
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Besides the planned analysis during the dose escalation, no further interim analyses are planned.
Only one attempt at dose reduction was done, and in the case of flare and treatment escalation, no further attempts at reduction were made.
High precision and normal tissue sparing allow dose escalation without further increase in morbidity and thereby increase the therapeutic ratio of RT.
"Further escalation will only isolate it further from the international community," Obama said in remarks on the South Lawn of the White House.
But the way forward is not through escalating antagonism -- if further escalation is even possible at this point.
James had no interest in further escalation.
"We take the position that any further escalation is unacceptable".
The move represents a further escalation of the crisis between the countries.
Drugs advisers fear further escalation in the drugs war ahead of an election.
Another North Korean nuclear test could lead the Trump Administration to respond — and potentially further escalation.
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