Sentence examples for escalation design from inspiring English sources

A 3 + 3 dose escalation design was employed.

The study plan employed randomized, open label, dose escalation design.

Exposing naïve patients to an MTD achieved with intra-patient dose escalation design may be unsafe.

The continual reassessment method is a recommended dose escalation design for including patients in phase I clinical trials designed to estimate the maximum tolerated dose.

A structured dose escalation design can reveal dose-dependent effects and adverse effects, crossover studies can demonstrate change, presurgical studies can define efficacy, interictal discharges and photosensitivity models can explain changes in seizure features, transcranial magnetic stimulation evaluates hyperexcitability.

Patients received DAC 20 mg/m2 intravenously daily for 5 days followed by rapamycin from day 6 to day 25 at doses of 2 mg, 4 mg, and 6 mg/day in a standard 3 + 3 dose escalation design.

Seven dose escalation designs used to find the maximal tolerated dose in cancer trials were investigated for our problem of determining the minimal effective dose (LED) in preventing pregnancies over 1 year.

Refractory CRPC patients were enrolled onto this 3+3 dose escalation designed study.

The study had a standard 3 + 3 dose-escalation design to define the maximum-tolerated dose.

GO was administered ≥60 days after alloHSCT in 2 doses (8 weeks apart), following a dose-escalation design (4.5, 6, 7.5, and 9 mg/m2).

Three regimens were investigated in a 3+3 dose-escalation design: 3 mg × 6 (dose level 1), 3 mg × 1, then 10 mg × 5 (dose level 2) and 3 mg × 1, 10 mg × 1, then 30 mg × 4 (dose level 3) administered over 4 weeks.