An ideal dose response trial is placebo controlled, uses multiple doses or a controlled dose-escalation schedule, consists of repeated visits with collection of numerous end points over time and controls for all potential sources of variability.
Antibiotic de-escalation, which consists of the initial institution of empiric broad-spectrum antibiotics followed by antibiotic streamlining driven by microbiological documentation, is thought to provide maximum benefit for the individual patient, while reducing the selection pressure for resistance.
De-escalation, which consists of the initial institution in severely ill patients of broad-spectrum antibiotics covering the most probable causative pathogens followed by antibiotic streamlining driven by microbiological documentation, is thought to provide maximum benefit for the individual patient, while reducing the selection pressure for resistance [ 11, 12].
Sertraline will be administered at an initial dose of 50 mg once daily or matching placebo followed by a dose escalation strategy consisting of 50 mg increments at 2 week intervals (as tolerated) to a maximum dose of 200 mg.
During phase I, the escalation groups consisted of 7 (5 mg/m2 PEG-Dox), 4 (10 mg/m), 3 (15 mg/m) and 4 (20 mg/m) patients.
Tsien et al. [12] determined the maximum tolerated dose in 38 consecutive patients treated with a dose escalation scheme consisting of concurrent TMZ delivery and 66 to 81 Gy over 6 weeks.
The phase I, dose-escalation trial consisted of 5 weeks of once-weekly Docetaxel (on day 3 of every week) concurrent with radiotherapy at a dose of 2,4 Gy/day for 5 days/week for 5 consecutive weeks to a total dose of 60 Gy.
Opera consists of moments of escalation which can be compared with the "epiphanies" in the work of Joyce.
Poor performance consists of cost and time escalation, poor outcome quality and shortfall benefits.
Marital conflict was evaluated using the Korean version of the marital conflict index (see questionnaires in Additional file 1), which consists of eight items regarding conflictual situations including escalation, invalidation, negative interpretations, withdrawal and avoidance between couples.
