To address this, Kao et al. performed a dose-escalation analysis of sunitinib both before and during RTx.
Nine patients were recruited to the 0.6 mg m−2 dose group to have three patients that were evaluable for dose-escalation analysis.
Multifocal Candida colonization, and mechanical ventilation were associated with significantly lower rate of de-escalation by univariate analysis.
Factors associated with higher rate of de-escalation in univariate analysis were: sterile repeated mycological samples, empirical treatment, preemptive treatment, positive bacterial samples, apyrexia, and catecholamine withdrawal at 72 hours after initiation of antifungal treatment.
Among these factors, only the appropriateness of initial antibiotic therapy - odds ratio (OR) = 2.9, 95% confidence interval (CI) = 1.5 to 5.7, P = 0.002 - was associated with the performance of de-escalation in multivariate analysis (Table 3).
Rather we see both as highly interrelated and consequently an analysis of escalation cannot separate the two.
According to our analysis, this escalation in insulin regimens from the simple basal to the complex basal-bolus may result in a further gain in the proportion of type 2 diabetic patients attaining the HbA1c goal (63.5% with the basal-bolus regimen), which still leaves ∼33% of patients not at the target goal.
The escalation in the use and analysis of SAD patterns may represent a substitution of statistical elegance for ecological relevance.
If the information on onset date and cycle was missing or incomplete, these patients were excluded from the analysis of grade escalation.
Despite limited exposure (median 36 weeks), this analysis demonstrates that escalation of deferasirox to doses of >30 mg/kg per d effectively decreased serum ferritin compared with levels prior to dose escalation in patients whose serum ferritin levels were not adequately controlled before escalation.
