Sentence examples for escalation algorithm from inspiring English sources

The CRM was selected to demonstrate this, not because it is necessarily the best escalation algorithm but because it permits measurement of numerical criteria that allow overall trial performance to be assessed.

Docetaxel was escalated in two dose levels, 40 mg/m (DL 0) and 30 mg/m (DL −1), plus 40 mg/m cisplatin and 2000 mg/m fluorouracil per week using a 3 +3 dose escalation algorithm.

In a recent multicentre randomised controlled trial (RCT), Jensen and colleagues randomised 1,200 critically ill patients to either a standard clinical judgement arm (blinded to PCT levels) or a PCT-guided treatment arm with a mandatory drug-escalation algorithm and antimicrobial guidance based on daily PCT measurements [ 7].

Patient-targeted sedation protocols implement two main features: a structured approach to the assessment of patient pain and distress, coupled with an algorithm that directs drug escalation and de-escalation based on the assessments.

This study mainly highlights the current practice of a specific algorithm of de-escalation solely based on the available microbiological data, and highlights the barriers to using it more widely.

The American Diabetes Association and the European Association for the Study of Diabetes have published a joint treatment recommendation with an algorithm for the stepwise escalation of therapeutic steps in the course of type 2 diabetes (52).

The claims-based effectiveness algorithm incorporated biologic dose escalation or switching, addition of new disease-modifying agents, increase in oral glucocorticoid use and dose as well as parenteral glucocorticoid injections.

Consecutive groups of 5 or 10 participants will then be challenged a minimum of 2 weeks apart following a decision-making algorithm for dose escalation/de-escalation (see figure 1).

Dose escalation and low adherence led to lower algorithm-defined effectiveness for infliximab and abatacept.

In contrast to 'patient-targeted sedation protocols', no formal algorithm has been established for drug escalation.

Prior to the execution of the study a dosing algorithm was designed allowing maximally 30% dose escalations, which was arbitrarily chosen for safety reasons.