If antimicrobial change consisted of escalation and de-escalation (i.e. switch to or addition of an antibiotic with a broader spectrum but also withdrawal of another antibiotic), the patient was assigned to "escalation group" for statistical analysis.
"If parties want to try – and I believe they do want to move to a de-escalation – I think there are sets of choices that are available," he said, expressing hope that "we can seize this moment and pull back from the precipice".
Moreover, the classical dose escalation rules (i.e. Fibonacci escalation, 3+3 design, dose-effect and dose-toxicity relationships) may not be suitable for MTA phase 1 trials.
Sensitivity and specificity of the sign of spectrum score ∆ to predict antimicrobial steward de-escalation opinion (i.e., reference standard) were calculated.
In some treatment centers, a slower re-escalation scheme (i.e., longer than the usual 2 weeks) after temporary treatment interruption has been employed.
In 2009, while serving with the State Department in Afghanistan, I could no longer go along with the war, let alone its escalation, and I resigned in protest.
On the other hand, there's always a danger of escalation, which I'm making every effort to prevent".
A two center, dose escalation phase I study of rViscumin was carried out.
