Exact(1)
R115777 was started at 300 mg b.i.d. in the first patient, but based on emerging data from other studies, for subsequent patients the starting dose was reduced to 200 mg b.i.d., with an escalating scheme for irinotecan, starting at 200 mg m−2 and escalating steps of 50 mg m−2 up to the registered single-agent dose, 350 mg m−2.
Similar(58)
Following an escalating dose scheme, inhibitor concentrations were doubled when virus-induced cytopathicity became detectable microscopically.
In the first cohort only, a dose escalation scheme was applied where study drug was not escalated to the next dose level unless the safety and tolerability of the previous doses were acceptable by sponsor and clinical team.
Even Mr. McCaw's charitable interests have a way of escalating into grand schemes.
The estimated cost of £25,000 for the scheme escalated to nearly £100,000, most of which was raised by mortgage.
Two different ESAs escalating dosing schemes were used (Table 2) leading to the classification of chemotherapy-induced anaemic patients in responders and non-responders with a 50% response rate per group.
In effect, they are handing a guarantee of future stockmarket performance to their employees; something that would be very expensive to buy.Oddly enough, the Bank of England has played its part in escalating the costs of other British pension schemes.
The only purpose the various government housing schemes now serve is to hold escalating home prices up in the south until the election in May 2015.
In the longer term, many experts have expressed concerns over the escalating costs of the more than 100 NHS PFI schemes, where private firms pay to build hospitals but the taxpayer is forced to pay an annual fee or "mortgage".
Escalating volcanic unrest preceded this eruption, and an alert level scheme was created and used to simplify communication between scientists and the local officials.
Paris also recognizes one of mythology's mischievous tricksters in the person of his own cousin, Ulysses S. (Useless) Grant, who drags Paris and Fearless into a reckless extortion scheme that escalates into murder and mayhem.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com