"These activities may lead to O.A. and they definitely can escalate the progression of the condition".
Microfluidic and CFD circulation models were designed to mimic tumor progression by escalating flow complexity and chaoticity.
Romantic stories are ultimately character-driven rather than plot-driven -- they depend on character progression and escalating interaction.
For example, does it escalate with disease progression - that is, is the requirement for Aβ reduction lower if intervention is earlier (predementia/presymptomatic), and greater if intervention is later in disease (mild to moderate)?
In the Cape-Bev arm, treatment may be escalated after disease progression (PFS-1) by addition of irinotecan (CAPIRI-Bev); PFS-2 can then be investigated in patients after treatment intensification.
DCC alterations are apparent in the early stages, and UNC5C alterations escalate with the progression of the disease, suggesting that the cumulative alterations of netrin-1 receptors was a late event in gastric cancer progression and emphasizing the importance of this growth regulatory pathway in gastric carcinogenesis.
Women who had been suffering from UI for years decided to seek help, probably due to escalating symptoms connected with disease progression.
This first-in-human, phase I, open-label study assessed safety, pharmacokinetics, and antitumor activity of TRC105 in patients with advanced refractory solid tumors.Patients received escalating doses of intravenous TRC105 until disease progression or unacceptable toxicity using a standard 3 + 3 phase I design.Fifty patients were treated with escalating doses of TRC105.
Twenty-seven patients were treated in escalating dose cohorts of 0.5 3.5 mg/kg (equivalent to 0.15 1.03 mg/kg MMC) every 4 weeks for up to 12 cycles, unless disease progression or unacceptable toxicity occurred.
"This has become routine and is escalating, escalating, escalating".
The dispute keeps escalating.
