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Atherosclerosis is prevalent in MHD patients; these patients are known to have an escalating increment of carotid IMT compared with age- and gender-matched subjects [ 18– 20].
Dosages were escalated in increments of 2 mg/m2/course based on side effects and tolerance.
The radiation prescription dose was escalated in increments of 5 Gy.
The initial starting dose of irinotecan was 70 mg m−2, and was escalated by increments of 10 mg m−2 between dose levels.
The initial total dose was 28 Gy (RBE) and escalated in increments of 2 Gy (RBE), up to 50 Gy (RBE).
In the 1-h schedule, the dose of PM00104 was escalated by increments of 100%50%0% if grade 2 toxicity occurred, and 25% if grade 3 or 4 toxicity occurred), while in the 3-h schedule, in view of the higher starting dosing, doses were escalated by increments of 25%.
If no toxicity was observed during the first hour, then the dosage was escalated by increments of 50 mg/hour every 30 min to a maximum of 300 mg/hour.
Doses were escalated in 100% increments without toxicity in 24 pts from 3 mg m 2cycle 1up to 400 mg m 2cycle 1.
The drug is infused at an initial rate of 50 mg/hour, escalating to a maximum of 400 mg/hour in 50 mg increments every 30 min, providing hypersensitivity or infusion related reactions do not occur.
The macaques were gradually acclimated to morphine by starting with 1 mg/kg for 1 week and escalating to a final dose of 3 mg/kg in 1 mg/kg increments per week.
The price escalated in million-dollar increments so quickly that it was hard to tell where the bids were coming from.
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