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Atherosclerosis is prevalent in MHD patients; these patients are known to have an escalating increment of carotid IMT compared with age- and gender-matched subjects [ 18– 20].
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The radiation prescription dose was escalated in increments of 5 Gy.
The initial starting dose of irinotecan was 70 mg m−2, and was escalated by increments of 10 mg m−2 between dose levels.
The initial total dose was 28 Gy (RBE) and escalated in increments of 2 Gy (RBE), up to 50 Gy (RBE).
In the 1-h schedule, the dose of PM00104 was escalated by increments of 100%50%0% if grade 2 toxicity occurred, and 25% if grade 3 or 4 toxicity occurred), while in the 3-h schedule, in view of the higher starting dosing, doses were escalated by increments of 25%.
If no toxicity was observed during the first hour, then the dosage was escalated by increments of 50 mg/hour every 30 min to a maximum of 300 mg/hour.
Cohorts of three patients were treated with a fixed dose of 5 g m−2 treosulfan (Medac, UK), preceded by escalating doses of gemcitabine (Lilly Oncology, UK), commencing at a dose of 0.5 g.m and increasing in increments of 0.5 g m−2.
It is escalating out of control.
The escalating size of these histories is easily explained.
Figure 1 shows that the escalating dose of benzodiazepines rapidly decreases after initiation of dexmedetomidine.
It correlates with escalating levels of drinking status [ 7].
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