Exact(7)
In the phase I portion, 15 patients were treated according to an escalating dosage regimen designed to determine the maximum tolerated dose.
Subjects were enrolled into four sequential, escalating dosage groups (5, 25, 50 or 100 µg of rPA) formulated in phosphate buffered saline (PBS) or Alhydrogel® adjuvant resulting in 8 dosage/formulation groups as well as a placebo group (Figure 1).
(8%), but only 1 patient presented with persisting symptoms even after escalating dosage.
The symptom relief was evaluated under escalating dosage as described before.
In case of persisting symptoms, the patients underwent a second diagnostic EGD and functional testing, followed by escalating dosage (II) with esomeprazole 40 mg b.i.d. for another 4 weeks.
After 4 weeks of treatment with esomeprazole 40 mg q.d., 21 (88%) patients achieved complete symptom relief. 2 patients achieved symptom relief after escalating dosage of esomeprazole to 40 mg b.i.d.
Similar(53)
The study consisted of two 4 week phases, separated by a 1 week 'wash-out' period, in which patients received escalating dosages of either placebo or nortriptyline.
The trail is expected to commence in early 2015 and will test escalating dosages of transplanted cells and safety profile.
This is in contrast to chemoresistant cell lines generated in vitro, which are often derived from clonal variants that survive by escalating dosages of chemotherapeutics.
This study was conducted in 13 HIV positive patients and 5 uninfected health-volunteer to evaluate adverse events of escalating dosages.
Escalating dosages of sedatives in the face of increasing agitation is a genuine medical emergency that must be dealt with aggressively.
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