"In Sierra Leone they are probably achieving that in most of the country, the exception being the west of the country, which is currently dealing with escalating disease," he said, but added that "they should be able to meet the target in the coming weeks as additional bed capacity comes online".
Under the second mechanism, depression may arise as a consequence of more severe or escalating disease.
On the other hand, the higher leptin concentration observed here as early as one year of age and consistently reported in SGA individuals [40], [46] could contribute to a positive energy balance and later fat mass accretion, which in turn will induce insulin resistance leading to a vicious cycle of escalating metabolic diseases.
In 1999, Kunstler went long on Y2K, predicting "loss of comfort and modern convenience," possibly escalating into disease and chaos.
This improved safety has notably occurred despite an ageing population and escalating patient disease burden in the US.
Many escalate disease treatment even when it is futile or causes suffering.
The US Forest Service has warned it is at the "tipping point" of a crisis in dealing with escalating wildfires and diseases that are ravaging America's increasingly fragile forest ecosystems.
For example, does it escalate with disease progression - that is, is the requirement for Aβ reduction lower if intervention is earlier (predementia/presymptomatic), and greater if intervention is later in disease (mild to moderate)?
In the Cape-Bev arm, treatment may be escalated after disease progression (PFS-1) by addition of irinotecan (CAPIRI-Bev); PFS-2 can then be investigated in patients after treatment intensification.
In the introduction, the authors describe a 'step-wise approach' to managing desmoids, starting with NSAIDs and antioestrogens, and escalating treatment if disease progresses (Sturt and Clark, 2006).
Recent reports describe escalating rates of disease caused by pneumococcal serotypes not included in currently licensed pneumococcal conjugate vaccine (7PCV),[ 3, 4]including an increasing proportion of isolates having antibiotic resistance.
