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Thus, direct effects of glucotoxicity, oxidative stress, and low-grade inflammation act in a vicious circle that impairs insulin sensitivity, accelerates and escalates loss of β-cells, impairs endothelial function, and leads to microvascular and macrovascular disease.
Thus, direct effects of glucotoxicity, oxidative stress and low grade inflammation act in a vicious circle that impairs insulin sensitivity, accelerates and escalates loss of β-cells, impairs endothelial function and leads to microvascular and macrovascular disease (Fig. 2).
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In 2007, their attempt to sell the complex to a real estate developer, David Bistricer, for $1.3 billion was blocked by tenant groups and local officials, who protested the escalating loss of moderately priced housing.
Subjectively, the person feels an escalating loss of control over the drug or the act and instead comes to feel increasingly controlled by it.
Thus, by weakening barriers to hybridization, EDCs in the environment could further escalate loss of native aquatic biodiversity by accelerating the spread of invasive species.
The accumulated changes lead to deficiencies in enzymes involved in necessary metabolic and maintenance processes, over time causing an escalating loss of function with an inability to maintain replicative fidelity of the genome [ 2- 4].
Hayflick (2003) defines aging in biological systems as a stochastic process that occurs systemically after reproductive maturity in animals that reach a fixed size in adulthood and that it is then caused by the escalating loss of molecular fidelity that ultimately exceeds repair capacity.
Just when it seemed that the mortgage mess was ending, the Federal Housing Administration, the agency that insurers home mortgages, is said to be experiencing escalating losses.
The reality is that the Washington meetings will be dominated by talk about the escalating losses weighing on the world's leading banks, insurance companies and pension funds.
There are better ways to remedy shortages in some military specialties than imposing social policies that would escalate losses of experienced personnel who are not easily replaced.
SAN FRANCISCO — Twitter's financial filing for its Wall Street debut was chock-full of juicy tidbits, from the name of its richest founder to a list of its escalating losses.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com