Exact(4)
Similarly, celecoxib was not escalated above 400 mg twice daily due to emerging cardiac toxicity data from other trials [ 26].
Although an MTD was not reached, the dose of AS1402 was not escalated above 16 mg/kg, which was considered to be the maximum viable.
The dose was not escalated above 1300 mg m-2 where nausea and vomiting were severe, prolonged (greater than 24 h) and poorly controlled by anti-emetics.
It appears from our study that the dose of gemcitabine, in combination with platinum and paclitaxel, cannot be escalated above 1000 mg m−2 every 10 days, owing to hepatic toxicity.
Similar(56)
The situation has escalated".
Aid agencies are concerned that without better civilian protection, and in the wake of renewed violence, the number of people forced to flee their homes in the region could escalate above the current 440,000.
The trial did not escalate above 1.3 mg/m2 of bortezomib twice weekly or 1.6 mg/m2 of bortezomib weekly because previously reported single-agent bortezomib trials have reported significant toxicities above these doses [ 24, 25].
12 Many strategies have been employed to limit motor fluctuations, but as disease duration increases, typically the medication interval decreases, and the levodopa dosage will quickly escalate above the 800 mg threshold in the majority of sufferers.
Analysts caution that prices that escalate quickly above $140 could create a scenario that is actually harmful for Gulf economies.
Intracellular calcium level also escalated as mentioned above.
These numbers, which are already escalating well above comparable civilian levels, may also be undercounting the problem by not counting all the National Guard members and reservists who are not on active duty, some experts say.
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