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These novel methods make it possible to escalate the dose to the target and protect healthy tissue at the same time.
The questions remaining unclear are whether it is necessary to escalate the dose to the regions with rapid cell repopulation in the tumor target and, if so, by how much.
In an effort to escalate the dose of melphalan and to improve the efficacy, we designed a dose-escalation study of melphalan in conjunction with palifermin in patients with NRF, with the hope that a higher dose of melphalan can be administered with an acceptable degree of oral mucositis (OM).
This review focuses on methods that have been proposed, or are already in clinical use, to safely escalate the dose of radiation within the prostate.
Based on the patient's reluctance to escalate the dose of pramipexole, it was tapered off and replaced with carbidopa/levodopa 25/100 mg tablets titrated to a dose of 1.5 tablets three times per day.
In patients 13, 14, and 15, VPA levels were suboptimal, and patients 13 and 14 were unwilling to escalate the dose of drug.
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It was possible to escalate the doses of doxorubicin to levels four-fold higher than those of free doxorubicin.
If this level of suppression was achieved, then it was planned to escalate the doses still higher to establish whether further suppression of testosterone was possible.
For young patients with good performance status, HFRT holds the promise of radiobiologically escalating the dose and potentially improving local control while maintaining quality of life.
These studies are designed to explore the feasibility of de-escalating the dose levels of single dose-IGRT without compromising local tumor control.
In future, escalating the dose to these tumour regions might improve outcome.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com