Sentence examples for esc level from inspiring English sources

Besides, BrdU integration assay revealed that proliferating cell number in Rif1 knockdown Smad3−/− ESCs was significantly reduced to about the WT ESC level, suggesting that upregulation of Rif1 in Smad3−/− ESCs is one of the main factors enhancing ESC proliferation.

However, further studies are needed to assess the actual ability of AFiPSCs to restore telomere restriction fragment length to an ESC level, a subject of controversial discussion in the iPSC field [45], [56], [57].

In total, NANOG and pSTAT3 rapidly reactivated many key components of the naive pluripotency network to near ESC level, shedding light on their ability to drive fast and efficient reprogramming.

Normalised values are shown relative to ESC expression level.

Mitophagy would promote mitochondrial degradation during iPSC generation, allowing differentiated cells to reduce the amount of this organelle to ESC-like levels.

The second step in the process is that, in response to the mutual sensing between normal and defective ESCs, differential levels of c-Myc are established between "fit" and "unfit" cells.

Since Hdac6 is only partially required for Tip60-p400 function in ESCs, the levels to which Tip60 and Hdac6 target genes are misregulated within the ICM of Hdac6−/− embryos may not be severe enough to induce a developmental arrest.

The hollow fiber/organoid culture method allows for cultured ESCs to form an organoid, and the differentiating ESCs reach a level of functionality comparable to or better than that of primary mouse hepatocytes (Amimoto et al., 2011).

This means that at the molecular level, ESCs are distinct from E3.5 ICM or E4.5 Epiblast.

Here, we have shown that, under conditions that promote pluripotency, ESC contain high levels of β-catenin but its transcriptionally competent isoforms are tightly associated with membranes.

The first extensively-drug resistant (XDR) [ 3] gonococcal strains with high-level ESC resistance were also described recently [ 9, 17, 19].