Sentence examples for esc into a from inspiring English sources

It is characterised by the phenotypic transformation of the elongated fibroblast-like endometrial stromal cells (ESC) into a larger, spherical decidual cell.

However, it is conceivable that inactivation of a single Klf gene drives ESC into a new metastable state characterized by altered proliferation and differentiation features.

These efforts culminated in systematic roadmaps describing the extrinsic signals that guide human ESCs into a variety of endoderm and mesoderm germ layer derivatives (including liver, intestinal, bone and heart progenitors) through a series of bifurcating intermediate steps.

In order to combine the RT profiles in human ESCs into a unique reference system, we assigned each probe its median rank from the four experiments.

Wang and colleagues [ 34] recently derived a transfection and culture procedure utilising surfactant protein C promoter-driven neomycin expression to facilitate the differentiation of human ESCs into a more than 99% pure population of type II alveolar epithelial cells.

These observations suggest that the Flcn-Fnip1/2-Tfe3 module acts as a cell-fate switch that steers naive early epiblast and ESCs into a primed postimplantation state in vitro and in vivo.

Altogether, our observations support and extend the notion that in vitro differentiation of ESCs into a Bra-expressing population, exhibits several parallels with the definition and behaviour of the primitive streak during mammalian gastrulation beyond gene expression profiles [ 34, 67].

Our observation that conversion of primed human ESCs into a naive state is associated with upregulation of XIST and inactivation of X-linked gene expression is unexpected because conversion of mouse EpiSCs to the naive state leads to X chromosome reactivation (Guo et al., 2009; Silva et al., 2009).

Taken together, it is thus conceivable that the direct activation of Pax6 expression is involved in Notch-induced differentiation of ESC into radial glia in a context-dependent manner.

Similarly, we find a strong increase in Tcf15 expression as naive ESCs move into a primed ES-cell state and an early transient pulse of Tcf15 expression as naive ESCs move toward neural differentiation.

The key to success in stem cell therapy is to establish methods of properly differentiating ESCs into any particular type of tissue-specific stem cells.