The classification error estimators of sensitivity and specificity, common to genetic association studies, simply correspond in this case to European and North African classification success in an arbitrary link to each population group.
These factors can give rise to partial volume errors and loss of sensitivity and therefore must be accounted for in combining data from multiple subjects.
Subsequently we established the optimal value of r for each method as the one that minimizes the mean error in terms of sensitivity and specificity.
Standard errors of sensitivity, false discovery rate, and genomic distance estimates are estimated using 1,000 bootstrap samples.
The performance of the proposed models was evaluated by calculating the overall accuracy of prediction, sensitivity, specificity, non-error rate (arithmetic mean of sensitivity and specificity) [38, 39], and Matthews correlation coefficient (MCC) [40].
Currently there is no validated epidemiological definition of gout flare, and although we followed the definition used by other authors (cfr e.g. ref [ 14]), based on clinical measurements, we expect that some errors of sensitivity (failure to identify true gout flares) and specificity (identification of subjects who did not experience gout flares) may be inherent in the definition.
Although we regard the experiments reported here as informative for comparing algorithms, realism is hard to achieve both in simulations and in mock communities, so results may not be predictive of sensitivity and error rates that would be achieved on experimental data from environmental samples.
The equation evaluates the misclassification error rate according to the arithmetic mean of sensitivity and specificity.
Using a cut-off of 3 or more errors, the sensitivity and specificity of the Six Item Screener for diagnozing dementia was 88.7 and 88.0, respectively [ 20].
Technical innovations for accurate measurement of reaction time as well as frequency of errors enhance overall sensitivity, and on-line adjustment of level of difficulty may minimize ceiling or floor effects.
