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For example, Edena exercises an option to trim a few bases from these ends until a minimum coverage is reached; Euler-SR performs a preprocessing error correction step where errors in reads
The models usually take into account CG-content, distributions of coverage, of sequencing errors in reads and of genomic mutations.
Hence it is mandatory to detect and revise these sequencing errors in reads before assembly [ 2, 7].
Therefore, several algorithms first correct sequencing errors in reads and then assemble the error-corrected reads [ 13– 15].
Spaced seeds have also been applied to the problem of correcting errors in reads from high-throughput sequencers [ 48].
Although error correction eliminates the majority of errors in reads, in ~1% of the cases it introduces, rather than corrects, errors (Pevzner et al., 2008).
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Reading errors are typically due to chemical/optical errors in reading the SNPs and as a result lead to the insertion of a wrong base in a certain position.
But in fact, machines make errors in reading the cards -- more than enough errors to overcome Governor Bush's machine-count lead.
Even workers in nuclear power plants make "errors in reading gauges, interpreting indicator lights, and selecting the wrong button to push," Casner writes.
Their cognitive errors in reading speedometers and fuel meters as well as the required task time and their general satisfaction levels were measured.
This procedure can be used to flush out errors in reading the original SDF file, reading/writing SMILES (either due to stereochemistry errors or kekulization problems), and is also a test (to some extent) of the canonicalization code.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com