Exact(9)
The advantage of HRR is that the original DNA sequence is restored without any loss of information because it uses the sister chromatid as a template, making it an error-free method of repair.
Template switching is an error-free method of bypassing lesions, and these experiments indicate that the absence of template switching leads to increased mutagenesis due to the presence of 8-oxoG.
A majority of the repair genes overexpressed were in primary tumors with a poor prognosis; therefore, the authors speculate that primary melanoma cells are capable of undergoing metastasis and replication by using a fast and error-free method.
HRR uses thousands of bases of sequence homology either from a sister chromatid or a homologous chromosome during S/G2 phase and is the most error-free method of repair [ 30].
There are two ways a cell can fill in this gap: an error-prone method using a translesion polymerase to copy the damaged template or an error-free method using the newly formed sister strand as a template (template switching).
Since no error-free method to specify priors is available for complex biological phenomena, exploring a wide variety of prior specifications and combining results provides some solution to this problem.
Similar(51)
However BRCA1 and BRCA2 proteins have multiple functions including participating in a pathway that mediates repair of DNA double strand breaks by error-free methods.
To accommodate variation in substitution rates, we introduce a branch-length scaling factor and optimize it (separately) for both the error and error-free models, using methods recently described elsewhere [39].
No method reconstructs error-free genome alignments, and any particular alignment is likely to contain errors that can substantially influence downstream inference.
Syrian casualty-recording organisations do not claim that their figures capture all of the casualties, or that their methods yield error-free data.
Thus, at least until assembly and annotation methods become error-free, the results of high-throughput data collection and analyses often need careful investigation and/or experimental validation.
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