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Fitting errors are presented as mean absolute percentage error to indicate model performance.
An illustrative plot is generated for each smoothed function and how it affects the incidence rate (on the log – scale), with point wise ± 2 × standard error to indicate an approximate confidence interval.
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Minor points "There are no error bars to indicate biological or technical variability in Figure 3 or 4. " Error bars have been added to illustrate technical variability in Figure 3 and Figure 4, respectively.
The coupling factors have two roles to play: To ensure the tracking of the ratio of the squared magnitudes of the reference and the error signal To indicate the instantaneous coupling between the two quantities.
Additional correlation coefficients include the mean absolute error (MAE), to indicate the forecast performance: mathrm{M}mathrm{A}mathrm{E} = frac{1}{N}{displaystyle {sum}_{i=1}^Nleft|{I}_{mod.,i}-{I}_{mathrm{meas}.,i}right|} (4).
Therefore, we only considered signal changes that are higher than this error margin to indicate a substantial variation in emission of fibril-bound ThT.
Firstly, Figure 1 and Figure 5 do not have error bars to indicate reproducibility of the data.
Minor points There are no error bars to indicate biological or technical variability in Figure 3 or 4. The workflow of Figure 1 does not indicate that the right-hand-side pathway involved only PBMC, not whole blood.
In addition to this major problem there are a few other aspects of the paper that need to be addressed: Firstly, Figure 1 and Figure 5 do not have error bars to indicate reproducibility of the data.
Trial sequential monitoring boundaries were employed to control the risks for type I and II errors, and to indicate whether additional trials are needed.
22 Trial sequential monitoring boundaries are used to control the risks for type I and II errors and to indicate whether additional trials are needed.
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