DRiPs could be marked for proteasomal degradation because they contain inevitable errors in translational or post-translational processes for producing normal functional proteins.
These proteins were called as defective ribosomal products (DRiPs), "that never attain native structure owing to errors in translation or post-translational processes necessary for proper protein folding", but their exact nature remains to be defined.
We go on to derive the prediction, unique to frameshifting errors, that differences in translational robustness between the 5′ and 3′ ends of genes should be less pronounced in genomes with higher GC content.
The driving force for adding new amino acids is the reduction in Φ0, not the reduction in translational error.
Some changes may be indirect and provide a benefit that is offset by some unrelated cost (e.g., extended protein half-life, changes in level of inhibitory metabolites, increases in translational error rate).
This sequence design may not be desirable as the overexpression of this gene can lead to very rapid depletion of the specific cognate tRNAs resulting in tRNA pool imbalance, which can in turn cause an increase in translational errors [ 37].
The fact that the standard code minimizes the effects of translational error in comparison to the vast majority of randomly reshuffled codes has been demonstrated convincingly by many different authors using statistical arguments.
D90 for the target had low robustness against a translational setup error in the vertical direction and a rotational setup error in the pitch direction.
D2 for the spinal cord was sensitive to a translational setup error in the lateral direction and a rotational setup error in the roll direction.
In these cases, and particularly where accuracy across a large feature space is essential such as in translational genomics research, it is preferable that data errors are accounted for.
