The post-replication repair error-free prone pathway was also represented in our dataset, albeit by mutants that showed only slight MMS sensitivity (POL32, MMS2, RAD6, UBC13, RAD52, RAD5, RAD18).
It is generally believed that BRCA1 maintains genomic stability by promoting error free HR and suppresses error prone NHEJ [ 97- 99].
It is also possible that Srs2 could facilitate the generation of substrates needed for the error-prone or error free sub-pathways of PRR [45,54].
A shift from an AtRAD21-dependent, possibly error free HR repair, to an error-prone-AtRAD21-independent DNA dsb repair pathway could be at the origin of the increased hypersensitivity of the atrad21.1 atradoubledouble mutant to DNA dsb damage.
Two PRR subpathways exist in S. cerevisiae: one that is error prone and one that is error free.
In eukaryotes, this damage is normally repaired through two complementary repair pathways nonhomologous end joining, which is "error prone," and homologous recombination repair, which is "error free".
When DNA double-strand breaks occur, repair is either by homologous recombination, which is error free, or by non-homologous end joining, which is error prone.
Zhang, Y. et al. Error-free and error-prone lesion bypass by human DNA polymerase kappa in vitro.
Crystallographic snapshots show that the cFaPy lesions keep the anti geometry of the glycosidic bond during error-free and error-prone replication.
The preference for error-free or error-prone postreplication repair in Saccharomyces cerevisiae exposed to low-dose methyl methanesulfonate is cell cycle dependent.
Because of homology between Dpo4 and Pol η, such a dynamic screening mechanism might be utilized by Dpo4 and Pol η to regulate error-free versus error-prone bypass of oxoG and other lesions.
