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He believed it was based on the erroneous linkage of Nairac to the earlier murder of IRA man John Francis Green in County Monaghan – the same pistol was used in both attacks.
Initial linkage analysis identified a single marker with an erroneous linkage relationship.
Misclassification of one patient from the 'DYT14' family had led to incorrect locus assignment on the basis of erroneous linkage.
The overall genotyping error rate was estimated within the 0.0005-0.05 range, the "checkalleles" function was used to detect markers with erroneous linkage phases and the "droponemarker" function to spot suspicious markers.
The designation of some loci has never been replicated and is of questionable significance (e.g. DYT7 or DYT13), whereas others are known to be the result of incorrect assignations due to erroneous linkage (e.g. DYT9, DYT14 and DYT19) (Wider et al., 2008; Weber et al., 2011).
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"We have experienced erroneous linkages before and we will certainly cooperate if this case is proved and any authorities want to speak with us," Ebdon said.
This review illustrates frequent problems of carbohydrate moieties in wwPDB entries, such as nomenclature issues, incorrect N-glycan core structures, missing or erroneous linkages, or poor glycan geometry, and describes the carbohydrate-specific validation tools that are designed to identify such problems.
Long-range LD could be an artefact resulting from mis-assembly or mis-mapping – small-scale transpositions and duplications, or simply because the Xiphophorus maculates genome as a typical next gen draft might have erroneous linkages.
However, for future studies, the erroneous assumption of linkage for one quarter of identified transmission events could clearly be a major source of misclassification bias with a consequent high risk of inaccurate conclusions about risk factors for HIV-1 transmission or efficacy of interventions to reduce HIV-1 infectiousness.
This may have several possible explanations, including inbreeding depression, sex-biased ratio distortion, erroneous scoring, or linkage between molecular markers and distorting factors such as recessive lethal genes or incompatible alleles.
Alternatively, BLAST results for Astyanax GBS markers (or the larger Astyanax sequences to which they were aligned) may include paralogous genes or otherwise ambiguous results that could lead to erroneous links between a linkage group and a Danio chromosome.
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