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Low-cost combination vaccines containing IPV could provide reliable and continuous immunization in the post-polio eradication period.
Although hexavalent vaccines may reach public markets at reasonable prices during the post-polio eradication period, they are much less likely to become the exclusive form of pediatric vaccine unless their inherent technical and pricing disadvantages can be successfully resolved.
20 subjects from the placebo group, whose infection has disappeared probably due to the intake of antibiotics that were given to them by their family physicians, were not included due to the unknown length of eradication period.
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According WHO recommendations, during the pre-eradication period the national choice of vaccines must include OPV or IPV, or a combination of both [ 24].
The use and life cycle of an IPV-containing hexavalent vaccine will evolve during the peri- and post-eradication period as polio immunization practices are refined.
UNICEF together with other partners is working on developing a polio vaccine stockpile to support the post-eradication period and the development by WHO of post-eradication immunization policies.
One issue is uncertainty about what the useful life cycle of a hexavalent vaccine containing IPV will be in light of evolving polio immunization practices during the peri- and post-eradication period.
For cases of successful eradication, the period of known infection was usually less than 12 months, whereas failed eradication usually occurred where long-term infection was evident.
Four hundred and ninety patients received eradication during the period of the study, 469 were evaluable.
All patients who had H. pylori eradication during the period were included.
The mean (SD) period from eradication therapy to endoscopy of these 18 cases was 28 (32) months.
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