Thus, to maximize treatment efficacy using ADCs, cytotoxic potency of payload is required to be high enough to effectively eradicate target cells, ideally in the picomolar range.
9 These responses exert their pathogenic effect by inducing apoptosis of mTNFα-bearing cells; therefore, biological-free remission is highly expected in some patients under remission by IFX and ADA therapy because their mechanisms of action enable them to eradicate target cells producing inflammatory cytokines in joints of the responsive patients.
Δx i (t) = x i (t+ -x i (t+ -x = 1, 2, Δz(t) = z(t+)-z(t), T is the period of the impulse for predator in order to eradicate both target pests, protect non-target pest (or harmless insect) from extinction and drive target pest to extinction, or control target pests at acceptably low level to prevent an increasing pest populations from causing an economic loss.
From an archipelago perspective, an effective means to reduce reintroduction risk is to eradicate the target invasive species from the entire archipelago and thus eliminate readily available sources.
One way to reduce reintroduction risks is to eradicate the target invasive species from an entire archipelago, and thus eliminate readily available sources.
An effective chemotherapeutic should eradicate a target cancer and leave no trace for downstream analysis by sequencing.
In cancer therapy, a therapeutic agent needs to (at least) control malignant cell growth, and preferably be able to kill and eradicate the target cells.
By the end of the episode we find out that Will is actually Hannibal's agent, playing right into his traps and behaving so predictably that Hannibal is able to use him to eradicate his targets.
Although engagement of TLR3 and TLR4 pathways alone, for example, may not be sufficient to eradicate tumors, targeting these receptors could be considered as a supplement to therapy until mechanisms of glioma cell suppression on microglia are more clearly understood.
Darling made no mention of the 2010 commitment, looking ahead to the longer-term target of eradicating child poverty by 2020.
